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排序方式: 共有193条查询结果,搜索用时 21 毫秒
31.
Weisshoff H Preiss A Nehls I Win T Mügge C 《Analytical and bioanalytical chemistry》2002,373(8):810-819
A hyphenated HPLC-(1)H NMR method for the identification and quantification of PAHs in soil samples has been developed and applied to a PAH reference sample provided by the Federal Institute for Materials Research and Testing (BAM, Berlin, Germany). The results were compared with those obtained by HPLC-DAD, HPLC-F, and GC-MS analyses of the same sample. 相似文献
32.
Winé G Matta J Tessonnier JP Pham-Huu C Ledoux MJ 《Chemical communications (Cambridge, England)》2003,(4):530-531
Beta zeolite supported on silicon carbide, with high thermal conductivity and high mechanical strength, was successfully used as an active and stable catalyst for Friedel-Crafts reactions in a fixed bed configuration. 相似文献
33.
Viel A Genuardi M Lucci-Cordisco E Capozzi E Rovella V Fornasarig M Ponz de Leòn M Anti M Pedroni M Bellacosa A Percesepe A Covino M Benatti P Del Tin L Roncucci L Valentini M Boiocchi M Neri G 《Community genetics》1998,1(4):229-236
OBJECTIVE: Identification of clinical and molecular characteristics associated with constitutional MLH1 and MSH2 mutations and definition of a stepwise strategy for the selection of colorectal cancer (CRC) patients amenable to MLH1 and MSH2 genetic testing. METHODS: 90 unrelated CRC patients were initially selected on the basis of either familial or early onset occurrence of CRC. They were screened for the presence of constitutional MLH1 and MSH2 mutations and for microsatellite instability (MSI). RESULTS: 16 pathogenetic mutations (9 MLH1 and 7 MSH2) were identified in 41% of Amsterdam hereditary nonpolyposis colorectal cancer (HNPCC) families, 5% of suspected HNPCC families, and 14% of sporadic early-onset CRC patients. The presence of the mutations correlated with MSI, with early age of onset and proximal location of the tumor, and with the presence of some extracolonic tumors of the HNPCC spectrum and/or multiple tumors in the family. CONCLUSIONS: Evaluation of clinical and molecular characteristics is useful for the identification of candidates to MLH1 and MSH2 mutational analysis and allows the application of a rational approach to genetic testing. 相似文献
34.
Bernazzani L Duce C Micheli A Mollica V Sperduti A Starita A Tiné MR 《Journal of chemical information and modeling》2006,46(5):2030-2042
In this paper, we report on the potential of a recently developed neural network for structures applied to the prediction of physical chemical properties of compounds. The proposed recursive neural network (RecNN) model is able to directly take as input a structured representation of the molecule and to model a direct and adaptive relationship between the molecular structure and target property. Therefore, it combines in a learning system the flexibility and general advantages of a neural network model with the representational power of a structured domain. As a result, a completely new approach to quantitative structure-activity relationship/quantitative structure-property relationship (QSPR/QSAR) analysis is obtained. An original representation of the molecular structures has been developed accounting for both the occurrence of specific atoms/groups and the topological relationships among them. Gibbs free energy of solvation in water, Delta(solv)G degrees , has been chosen as a benchmark for the model. The different approaches proposed in the literature for the prediction of this property have been reconsidered from a general perspective. The advantages of RecNN as a suitable tool for the automatization of fundamental parts of the QSPR/QSAR analysis have been highlighted. The RecNN model has been applied to the analysis of the Delta(solv)G degrees in water of 138 monofunctional acyclic organic compounds and tested on an external data set of 33 compounds. As a result of the statistical analysis, we obtained, for the predictive accuracy estimated on the test set, correlation coefficient R = 0.9985, standard deviation S = 0.68 kJ mol(-1), and mean absolute error MAE = 0.46 kJ mol(-1). The inherent ability of RecNN to abstract chemical knowledge through the adaptive learning process has been investigated by principal components analysis of the internal representations computed by the network. It has been found that the model recognizes the chemical compounds on the basis of a nontrivial combination of their chemical structure and target property. 相似文献
35.
Ronald A. Farrar‐Tobar Bartosz Wozniak Arianna Savini Sandra Hinze Sergey Tin Johannes G. deVries 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(4):1141-1145
Herein, we report on the use of the iron pincer complex Iron‐MACHO‐BH, in the base‐free transfer hydrogenation of esters with EtOH as a hydrogen source. More than 20 substrates including aromatic and aliphatic esters and lactones were reduced affording the desired primary alcohols and diols with moderate to excellent isolated yields. It is also possible to reduce polyesters to the diols with this method, enabling a novel way of plastic recycling. Reduction of the renewable substrate methyl levulinate proceeds to form 1,4‐pentanediol directly. The yields are largely governed by the equilibrium between the alcohol and the ethyl ester. 相似文献
36.
Annemarie Marckwordt Fatima ElOuahabi Hadis Amani Sergey Tin Narayana V. Kalevaru Paul C. J. Kamer Sebastian Wohlrab Johannes G. deVries 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(11):3524-3528
Use of ZrO2/SiO2 as a solid acid catalyst in the ring‐opening of biobased γ‐valerolactone with methanol in the gas phase leads to mixtures of methyl 2‐, 3‐, and 4‐pentenoate (MP) in over 95 % selectivity, containing a surprising 81 % of M4P. This process allows the application of a selective hydroformylation to this mixture to convert M4P into methyl 5‐formyl‐valerate (M5FV) with 90 % selectivity. The other isomers remain unreacted. Reductive amination of M5FV and ring‐closure to ?‐caprolactam in excellent yield had been reported before. The remaining mixture of 2‐ and 3‐MP was subjected to an isomerising methoxycarbonylation to dimethyl adipate in 91 % yield. 相似文献
37.
Jarinee Kiang-ia Rahut Taeudomkul Pongthep Prajongtat Padetha Tin Apichart Pattanaporkratana Nattaporn Chattham 《Molecules (Basel, Switzerland)》2021,26(14)
Continuous rotation of a cholesteric droplet under the heat gradient was observed by Lehmann in 1900. This phenomenon, the so-called Lehmann effect, consists of unidirectional rotation around the heat flux axis. We investigate this gradient heat effect using infrared laser optical tweezers. By applying single trap linearly polarized optical tweezers onto a radial achiral nematic liquid crystal droplet, trapping of the droplet was performed. However, under a linearly polarized optical trap, instead of stable trapping of the droplet with slightly deformed molecular directors along with a radial hedgehog defect, anomalous continuous rotation of the droplet was observed. Under low power laser trapping, the droplet appeared to rotate clockwise. By continuously increasing the laser power, a stable trap was observed, followed by reverse directional rotation in a higher intensity laser trap. Optical levitation of the droplet in the laser beam caused the heat gradient, and a breaking of the symmetry of the achiral nematic droplet. These two effects together led to the rotation of the droplet under linearly polarized laser trapping, with the sense of rotation depending on laser power. 相似文献
38.
Ilaria Bonaduce Leslie Carlyle Maria Perla Colombini Celia Duce Carlo Ferrari Erika Ribechini Paola Selleri Maria Rosaria Tiné 《Journal of Thermal Analysis and Calorimetry》2012,107(3):1055-1066
This article presents a multi-analytical approach to investigating the drying, polymerisation and oxidative degradation of
linseed oil, which had undergone various treatments known to be undertaken during the nineteenth century in preparation for
painting. The oil was mechanically extracted from the same seed lot then processed by different methods: water washing, heat
treatments, and the addition of driers, with and without heat. The oil was prepared in 1999 within the framework of the MOLART
project. We compared thermogravimetric analysis (TG), which yields macromolecular information, with gas-chromatography mass-spectrometry
(GC/MS) and direct exposure mass spectrometry (DE-MS), which provide molecular information. This comparison enabled us to
elucidate the role of pre-treatment on the composition of the oil. TG and oxygen uptake curves registered at a constant temperature
helped us to identify the different physical behaviour of the oil samples, thus highlighting the presence of hydrolysed, oxidised
and crosslinked fractions, as a consequence of the different pre-treatments. GC/MS was used to characterise the soluble and
non-polymeric fraction of the oil, to calculate the ratios of palmitic to stearic acid (P/S), and azelaic to palmitic acid
(A/P), and to further evaluate the effects of oil pre-treatments. DE-MS using chemical ionisation with CH4, enabled us to establish the chemical composition of the oil in different stages of ageing. DE-MS proved to be a useful tool
for a simultaneous semi-quantitative characterisation of the free fatty acids, monoglycerids, diglycerides and triglycerides
present in each sample. The combination of thermal analysis with GC/MS and DE-MS enabled a model to be developed, which unravelled
how oil pre-treatments produce binders with different physical–chemical qualities. 相似文献
39.
Shuchen Hsieh Pei‐Ying Lin Chiung‐Wen Hsieh I‐Tin Li Shu‐Ling Hsieh Chih‐Chung Wu Yun‐Shan Huang Huay‐Min Wang Li‐Wei Tu Kuang‐Hung Cheng Hay‐Yan Jack Wang Deng‐Chyang Wu 《中国化学会会志》2012,59(8):929-933
Carcinoma cell differentiation stage is an important indicator of cell behavior. For example, cell mobility is much higher for poorly‐differentiated hepatocellular carcinoma SK‐Hep‐1 cells than for well‐differentiated HepG2 cells. In this study, we have cultured HepG2 and SK‐Hep‐1 cells on chemically patterned polydimethylsiloxane (PDMS) substrates to observe differences in the adhesion properties and cell structure that occur due to the patterns. Both cell lines showed a preference for the hydrophobic regions on the patterned PDMS surface with SK‐Hep‐1 cells achieving a higher density than HepG2 for the same cell‐count solutions. Further, SK‐Hep‐1 cells adopted the square or hexagonal shape of the surface patterns while HepG2 cells maintained their more rounded shape. AFM force measurement arrays were also performed on the cell surfaces to measure and map adhesion values between the tip and cell surface membrane. These results demonstrate that, in addition to cell shape and size, adhesion expression in hepatocellular carcinoma cells is differentiation stage dependent. Further, the ability of the SK‐Hep‐1 cells to adopt the shape of the substrate pattern indicates they are more structurally labile, which may contribute to their higher mobility. 相似文献
40.
Rosemarie Philipp Olaf Hanebeck Sebastian Hein Wolfram Bremser Tin Win Irene Nehls 《Accreditation and quality assurance》2010,15(3):141-146
The Federal Institute for Materials Research and Testing (BAM), Germany, has issued a series of large volume ethanol in water
certified reference materials (CRMs), primarily developed for the calibration of evidential breath alcohol analyzers in Germany.
The certified parameter is the ethanol mass concentration at 20 °C. When used in a wet bath simulator, the solutions deliver
gas samples that meet the requirements set by the Organization of Legal Metrology for calibration of breathalyzers. The materials
were prepared gravimetrically by spiking of ethanol into water in single 5 L units. A complete uncertainty budget for the
preparation process has been established. The purity of the commercial ethanol stock solution was identified to be the main
source of uncertainty. For stability and homogeneity measurements and for the verification of the gravimetric mass concentration
of the CRMs, a robust high-precision gas chromatography, with flame-ionization detection method for ethanol determination
in aqueous samples was developed and validated. The good performance of this method has been demonstrated in several international
comparisons organized by the Consultative Committee for Amount of Substance—Metrology in Chemistry at the International Bureau
of Weights and Measures. 相似文献